Research

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侾丏Activation and inactivation processes of cell viability by atmospheric pressure plasma flow


We aim at clarifying the effects on cells by chemical species generated by plasma, and aim for the fundamental study and the application.


We have now studied about the activation and inactivation mechanism of cell viability by a plasma flow, and the transport mechanism of chemical species generated by the plasma flow.

For Further Details:

T. Sato et al., J. Phys. D: Appl. Phys., 44 (2011), 372001

M. Yokoyama et al., BBRC, 450 (2014), 1266

T. Miyahara et al., AIP Advances, 4 (2014), 047115

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Fluorescence image of HeLa cells. Regular (Left). Cell death after exposure (Right).

 

俀丏Sterilization device and mechanism by low-temperature plasma at atmospheric pressure


Microwave argon plasma flow


To reduce infection risks of new influenza, nosocomial infection and so on, and to develop next-generation medical instruments, we aim at clarifying generation and transportation mechanisms of a plasma flow by experimental and computational analyses and we also aim at identifying the central factor of sterilization effect and clarifying sterilization mechanism.


For Further Details:

T. Sato et al., Applied Physics Letters, 89 (2006), 073902.

T. Sato et al., IEEE Trans. Industry Appli., 42 (2006), 399.

T. Sato et al., IEEE Trans. Industry Appli., 43 (2007), 1159.

T. Miyahara et. al, Europhysics Letters, 86 (2009), 45001.

T. Sato et al., New Journal of Physics, 11 (2009), 115018.

(International Patent Application)
PCT/JP2005/15431,
Special Application
2007-001999,
Patent
2008-06604




Photograph丂丂 丂丂N2*
丂丂丂丂丂Visualization


Effect of plasma flow on E coli. Treated (R)



仜 Sterilization in a tube


Application to medical equipments such as catheter sterilization by radical generation, transport and concentration using plasma flow control. For example, optimum sterilization conditions are 5 min, 70 亷 and 13 W for a tube of 100 mm length and 3 mm i.d.


For Further Details:

T. Sato et al., Plasma Processes and Polymers, 5 (2008), 606.

T. Sato et al.., IEEE Trans. Industry Appli., 45 (2009) , 44.

Patent No.4898635, No.4902842

(International Patent Application)
PCT/JP2006/315958
,
Special Application 2005-270014
,
Special Application 2006-220400
, etc.




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Twin voltex丂丂丂丂丂N2* emission



Computational analysis of streamer propagation



Plasma autoclave


Development of steam sterilization system for medical equipments at 100亷 and atmospheric pressure by controlling OH radical generation and transport. We succeeded in sterilizing bacteria spores within 30 min.


For Further Details:

T. Furui, T. Sato, JSME Journal B, 70 (2008), 879. (in Japanese)

Patent No.4881249

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Steam plasma flow



俁丏Initiation and propagation mechanism of underwater streamers


We aim at developing underwater plasma generation device for cell irradiation by clarifying and controlling underwater microscopic high-speed discharge phenomena.

We clarified that a primary streamer propagated intermittently synchronized with appearance of pulsed currents and a secondary streamer propagated with around 20 km/s during a continuous current appears.

For Further Details:

H. Fujita et al., J. Appl. Phys. 113 (2013), 113304.

H. Fujita et al., EPL, 105 (2014), 15003.

H. Fujita et al., IEEE Trans. Plasma Sci. 42 (2014), 2398.

H. Fujita et al., J. Appl. Phys. 116 (2014), 213301.

H. Fujita et al., Journal of the Institute of Electrostatics Japan, 39 (2015), 21. (Institute of Electrostatics Japan Paper Award)


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Propagation of underwater primary streamer

Propagation of underwater secondary streamer



係丏Behavior of plasma-induced cavitation bubbles

We conduct a fundamental research toward the development of underwater plasma medical devices by clarifying the rebound behavior of the bubbles generated by underwater plasma.


We have clarified that the rebound behavior changes because the hydrogen gas is generated at the time of bubble generation by using high heat source such as laser or spark, and that the hydrogen gas is introduced into the bubbles, through the collaborative research with Professor Farhat's group at Ecole Polytechnique Federale de Lausanne (EPFL, Switzerland).

For Further Details:

T. Sato et al., APL102 (2013), 074105.

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Behavior of bubbles generated in water



俆丏Chemical transport by plasma actuator

We clarify chemical transport mediating gas-liquid interface and aim for an application to plasma medicine.

We have clarified that the plasma generated on the water surface forms thermal flow field in the gas phase and the flow is induced under water, and that the chemical species generated in the gas phase dissolve in water and are transported mainly by convection flow, through the collaborative research with Professor Morfill's group at Max-Planck Institute (Germany). We have also clarified the details of the generation mechanism of induced flows by plasma

For Further Details:

T. Shimizu et al., New J. Phys., 13 (2011), 053025.

T. Shimizu et al., J. Photochem. Sci. Tech., 24 (2011), 421R.

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High speed images of plasma induced flow in the plasma-water system.