Intelligent Fluid Systems Division

Biofluids Control Laboratory

Concurrent Professor
Toshiyuki Hayase

Associate Professor
Makoto Ohta


     The focus of the biofluids control laboratory is to develop new concept of implant especially based on flow and to establish new methods for evaluating the implants. For example, when you treat a cerebral aneurysm with endovascular treatment, you should know the effects of medical devices on controls of blood flow.
     The flow may depend on the geometry, materials and clinical conditions. Since these are so big issues, we collaborate with biomaterial groups, biomechanical groups, and medical groups to gather their top knowledge. This field is called as a life science, or biomedical engineering. The aim of this lab is to support and improve our social quality of life by biomedical engineering.



     In-vitro simulation of blood flow is used as an operating simulation with medical devices, education of operation for younger generation, and measurement of blood flow. Poly (vinyl alcohol) hydro-gel is good performance to mimic blood vessel with transparent and to establish an operation method.

Collaboration: Geneva University Hospital, Institute of Frontier Medical Sciences, and companies.




Biomodelling with PVA hydro-gel having good elasticity and transparent.

Subtracted Vortex Centres Path line method with Cinematic Angiography for evaluating flow in cerebral aneurysm


    It is important to measure flow speed in cerebral aneurysms when treated by interventional neuroradiology such as coiling or stenting. We have developed the method for measurement of flow speed using cinematic angiography, and the possibilities were verified with a model in this study.

The successive images with CA using an in-vitro model. You can see the fluid movement dynamically and you will measure flow speed with tracing this movement.

Impact of stent design and positioning effect onto intra aneurysmal flow

    Intracranial stent is used as flow control in cerebral aneurysm. Stent characteristics such as strut size, porosity and cell shape influence the changes in intra-aneurysmal flow. The purpose of this computer simulation study was to visualize the flow pattern over the entire neck area of a side wall aneurysm while changing the stent parameters.

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Intelligent Fluid Systems Division

Bioflulids Control Laboratory