{"id":33,"date":"2021-03-12T15:56:04","date_gmt":"2021-03-12T06:56:04","guid":{"rendered":"http:\/\/www.ifs.tohoku.ac.jp\/eng\/?page_id=33"},"modified":"2025-04-24T14:55:39","modified_gmt":"2025-04-24T05:55:39","slug":"isbel","status":"publish","type":"page","link":"https:\/\/www.ifs.tohoku.ac.jp\/eng\/research\/dv_crfrd\/isbel\/","title":{"rendered":"Integrated Simulation Biomedical Engineering Laboratory"},"content":{"rendered":"<div class=\"research\">\r\n<div class=\"header\">\r\n<div class=\"wrapper\">\r\n<div class=\"clearfix\"><ul class=\"breadcrumb\">\n<li><a href=\"\/jpn\/\">TOP<\/a><\/li>\n<li><a href=\"https:\/\/www.ifs.tohoku.ac.jp\/eng\/research\/\">Research<\/a><\/li>\n<li><a href=\"https:\/\/www.ifs.tohoku.ac.jp\/eng\/research\/dv_crfrd\/\">Creative Flow Research Division<\/a><\/li>\n<li>Integrated Simulation Biomedical Engineering Laboratory<li>\n<\/ul><\/div>\r\n<h2>Creative Flow Research Division<\/h2>\r\n<h3>Integrated Simulation Biomedical Engineering Laboratory<\/h3>\r\n<div class=\"clearfix\">\r\n<ul class=\"professor\">\r\n<li><img decoding=\"async\" src=\"\/jpn\/wp-content\/themes\/ifs\/images\/research\/professor\/kenichifunamoto_v2.jpg\" \/>\r\n<p><span>Professor<\/span>Kenichi Funamoto<\/p>\r\n<\/li>\r\n<\/ul>\r\n<\/div>\r\n<div class=\"clearfix\">\r\n<ul class=\"sdgs\">\r\n<li><img decoding=\"async\" src=\"\/jpn\/wp-content\/themes\/ifs\/images\/research\/sdgs_icon_e\/sdgs-03.jpg\" \/><\/li>\r\n<li><img decoding=\"async\" src=\"\/jpn\/wp-content\/themes\/ifs\/images\/research\/sdgs_icon_e\/sdgs-09.jpg\" \/><\/li>\r\n<\/ul>\r\n<\/div>\r\n<div class=\"clearfix\">\r\n<div class=\"labo\"><a href=\"https:\/\/sites.google.com\/view\/ifs-funamoto-eng\/home\" target=\"_blank\" rel=\"noopener\">Enter the Lab Page<\/a><\/div>\r\n<\/div>\r\n<\/div>\r\n<\/div>\r\n<div class=\"gray\">\r\n<div class=\"wrapper\">For technical innovation of treatment and prevention for diseases, it is essential to elucidate mechanisms for homeostasis and <em>in vivo<\/em> phenomena related to development and progression of the diseases. We perform interdisciplinary research based on fluid engineering, integrating biomedical engineering and cell biology. Changes of an individual cell response, cell\u2014cell and cell\u2014extracellular matrix interactions, and tissues are investigated by reproducing <em>in vivo<\/em> microenvironments with microfluidic devices \u201corgan-on-chips\u201d and measurement-integrated simulation.<\/div>\r\n<\/div>\r\n<div class=\"contents\">\r\n<div class=\"wrapper\">\r\n<h4>Reproduction of <em>in vivo<\/em> microenvironments using microfluidic devices<\/h4>\r\n<div>Cells respond to mechanical stimuli caused by motion and blood flow and chemical stimuli by chemicals, and failures of such cellular functions possibly result in diseases or damages. In order to reproduce physiological and pathological <em>in vivo<\/em> microenvironments, we develop \u201c3-in-1 organ-on-a-chip\u201d which simultaneously controls oxygen tension and mechanical and chemical stimuli to cultured cells. The chip contributes to elucidation of phenomena in <em>in vivo<\/em> microenvironment, and is useful as a platform for drug discovery for diseases.<\/div>\r\n<div class=\"photo\">\r\n<div class=\"clearfix\">\r\n<ul class=\"single\">\r\n<li><img decoding=\"async\" src=\"\/jpn\/wp-content\/themes\/ifs\/images\/research\/division\/03_img\/funamoto1.jpg\" \/><\/li>\r\n<\/ul>\r\n<\/div>\r\n<\/div>\r\n<div class=\"clearfix\">\r\n<ul class=\"sdgs\">\r\n<li><img decoding=\"async\" src=\"\/jpn\/wp-content\/themes\/ifs\/images\/research\/sdgs_icon_e\/sdgs-03.jpg\" \/><\/li>\r\n<li><img decoding=\"async\" src=\"\/jpn\/wp-content\/themes\/ifs\/images\/research\/sdgs_icon_e\/sdgs-09.jpg\" \/><\/li>\r\n<\/ul>\r\n<\/div>\r\n<\/div>\r\n<\/div>\r\n<div class=\"contents\">\r\n<div class=\"wrapper\">\r\n<h4>Elucidation and control of cellular responses to hypoxic stresses<\/h4>\r\n<div>\r\n<p><span>An <em>in vivo<\/em> oxygen tension is lower than the atmospheric one and has spatial and temporal variations, affecting cell activity. In a tumor microenvironment, heterogeneous oxygen concentration is observed due to hyperproliferation of the cells and formation of immature vascular network. Such temporal and spatial variations of oxygen concentration activate migration of cancer cells and angiogenesis by vascular endothelial cells, leading to cancer progression and metastasis. We elucidate oxygen-dependent cellular dynamics and characteristics, e.g., cancer cell migration and vascular endothelial permeability, and investigate to control them.<\/span><\/p>\r\n<\/div>\r\n<div class=\"photo\">\r\n<div class=\"clearfix\">\r\n<ul class=\"single\">\r\n<li><img decoding=\"async\" src=\"\/jpn\/wp-content\/themes\/ifs\/images\/research\/division\/03_img\/funamoto2.jpg\" \/><\/li>\r\n<\/ul>\r\n<\/div>\r\n<\/div>\r\n<div class=\"clearfix\">\r\n<ul class=\"sdgs\">\r\n<li><img decoding=\"async\" src=\"\/jpn\/wp-content\/themes\/ifs\/images\/research\/sdgs_icon_e\/sdgs-03.jpg\" \/><\/li>\r\n<\/ul>\r\n<\/div>\r\n<\/div>\r\n<\/div>\r\n<div class=\"contents\">\r\n<div class=\"wrapper\">\r\n<h4>Hemodynamic analysis by integration of medical measurement and numerical simulation<\/h4>\r\n<div>Accurate diagnosis of circulatory diseases is a critical issue to realize a healthy society. Even a state-of-the-art medical equipment is not sufficient to measure the complete information on hemodynamics. The fastest supercomputer may perform an ultra-high speed computation (real-time computation), but is inherently incapable to reproduce the real blood flows due to the lack of the exact computational condition for the relevant flows. We are doing a research to realize an advanced medical care by understanding complex hemodynamics through measurement-integrated simulation of blood flows.<\/div>\r\n<div class=\"photo\">\r\n<div class=\"clearfix\">\r\n<ul class=\"single\">\r\n<li><img decoding=\"async\" src=\"\/jpn\/wp-content\/themes\/ifs\/images\/research\/division\/03_img\/funamoto3.jpg\" \/><\/li>\r\n<\/ul>\r\n<\/div>\r\n<\/div>\r\n<div class=\"clearfix\">\r\n<ul class=\"sdgs\">\r\n<li><img decoding=\"async\" src=\"\/jpn\/wp-content\/themes\/ifs\/images\/research\/sdgs_icon_e\/sdgs-03.jpg\" \/><\/li>\r\n<li><img decoding=\"async\" src=\"\/jpn\/wp-content\/themes\/ifs\/images\/research\/sdgs_icon_e\/sdgs-09.jpg\" \/><\/li>\r\n<\/ul>\r\n<\/div>\r\n<\/div>\r\n<\/div>\r\n<div class=\"footer clearfix\">\r\n<div class=\"wrapper\">\r\n<div class=\"labo\"><a href=\"http:\/\/www.ifs.tohoku.ac.jp\/sme\/index_e.html\" target=\"_blnak\" rel=\"noopener\">Enter the Lab Page<\/a><\/div>\r\n<\/div>\r\n<\/div>\r\n<\/div>","protected":false},"excerpt":{"rendered":"Creative Flow Research Division Integrated Simulation Biomedical Engineering Laboratory ProfessorKenichi Funamoto Enter the Lab Page For technical innovation of treatment and prevention for diseases, it is essential to elucidate mechanisms for homeostasis and in vivo phenomena related to development and progression of the diseases. We perform interdisciplinary research based on fluid engineering, integrating biomedical engineering [&hellip;]","protected":false},"author":1,"featured_media":0,"parent":42,"menu_order":3,"comment_status":"closed","ping_status":"closed","template":"","meta":{"_acf_changed":false,"footnotes":""},"class_list":["post-33","page","type-page","status-publish","hentry"],"acf":[],"aioseo_notices":[],"aioseo_head":"\n\t\t<!-- All in One SEO 5.0.1.1 - aioseo.com -->\n\t<meta name=\"description\" content=\"Creative Flow Research Division Integrated Simulation Biomedical Engineering Laboratory ProfessorKenichi Funamoto Enter the Lab Page For technical innovation of treatment and prevention for diseases, it is essential to elucidate mechanisms for homeostasis and in vivo phenomena related to development and progression of the diseases. We perform interdisciplinary research based on fluid engineering, integrating biomedical engineering\" \/>\n\t<meta name=\"robots\" content=\"max-image-preview:large\" \/>\n\t<link rel=\"canonical\" href=\"https:\/\/www.ifs.tohoku.ac.jp\/eng\/research\/dv_crfrd\/isbel\/\" \/>\n\t<meta name=\"generator\" content=\"All in One SEO (AIOSEO) 5.0.1.1\" \/>\n\t\t<meta property=\"og:locale\" content=\"en_US\" \/>\n\t\t<meta property=\"og:site_name\" content=\"Institute of Fluid Science, Tohoku University -\" \/>\n\t\t<meta property=\"og:type\" content=\"article\" \/>\n\t\t<meta property=\"og:title\" content=\"Integrated Simulation Biomedical Engineering Laboratory - Institute of Fluid Science, Tohoku University\" \/>\n\t\t<meta property=\"og:description\" content=\"Creative Flow Research Division Integrated Simulation Biomedical Engineering Laboratory ProfessorKenichi Funamoto Enter the Lab Page For technical innovation of treatment and prevention for diseases, it is essential to elucidate mechanisms for homeostasis and in vivo phenomena related to development and progression of the diseases. 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