Creative Flow Research Division
Integrated Simulation Biomedical Engineering Laboratory
Concurrent ProfessorMakoto Ohta
Reproduction of in vivo microenvironments using microfluidic devices
Elucidation and control of cellular responses to hypoxic stresses
An in vivo oxygen tension is lower than the atmospheric one and has spatial and temporal variations, affecting cell activity. In a tumor microenvironment, heterogeneous oxygen concentration is observed due to hyperproliferation of the cells and formation of immature vascular network. Such temporal and spatial variations of oxygen concentration activate migration of cancer cells and angiogenesis by vascular endothelial cells, leading to cancer progression and metastasis. We elucidate oxygen-dependent cellular dynamics and characteristics, e.g., cancer cell migration and vascular endothelial permeability, and investigate to control them.